In the 2040s, music is lost to humanity because it inevitably lures dangerous alien creatures called “D2”. The only thing capable of defeating them are super-powered young women with the power of music – “Musicarts” – and their magically bound handlers – “Conductors”. The Conductor Takt and his Musicart Destiny (who holds the power of Beethoven’s 5th Symphony) travel across the United States, righting wrongs and playing songs on their way to New York.