In an alternate history industrialized Europe where vampires are an acknowledged social minority, the eponymous Vanitas is a doctor in possession of the ancient “Tome of Vanitas”, named after the ancient vampire Vanitas, which makes him the heir to Vanitas. Teaming up with disgraced vampire Noé Archiviste, Vanitas uses the power of the Tome of Vanitas in order to cure vampires of metaphysical sicknesses affecting their True Names.